Sandhoff disease is a severe neurodegenerative glycosphingolipid (GSL) lysosomal storage disorder, currently without treatment options.One therapeutic approach under investigation is substrate reduction therapy (SRT).By partially inhibiting GSL biosynthesis, the impaired rate of GSL catabolism is balanced by a slower rate of influx of GSLs into the
Large-scale calibration and simulation of COVID-19 epidemiologic scenarios to support healthcare planning
The COVID-19 pandemic has provided stiff challenges for planning and resourcing in health services in the UK and worldwide.Epidemiological models can provide simulations of how infectious disease might progress in a population given certain parameters.We adapted an agent-based model of COVID-19 to inform planning Alpha Lipoic Acid and decision-maki
Computational fluid dynamics approach for energy savings evaluation in core annular flow of a horizontal T-pipe
The application of core annular flow (CAF) has become an interesting solution in transporting heavy oil through pipeline because of its energy reduction and cost efficiency.At the same time, the CAF in pipe with hydraulic fittings and the problem of unstable CAF are the part of some big issues in using CAF techniques.This study intended NAPKIN to i
Fate of Ukrainian fists: deportation, loss, attempts homecoming
The article refers to the Bolshevik genocide against prosperous Ukrainian peasantry, which the communist authorities, referring to the category of exploiters deported in the undeveloped eastern and northern regions of the USSR, to reduce resistance to forced collectivization of farmers.In particular archival documents highlighted the course of depo